In some cases, large-scale carcass disposal has been possible by obtaining exceptions to existing regulations, such as for burial and burning. Although most of these exceptions have been approved, it is preferable to identify appropriate methods for large-scale carcass disposal and to facilitate regulatory compliance before the need arises. Advance planning should prepare appropriate policies that facilitate compliance of carcass disposal methods with regulatory agencies.

Carcasses can be spread over wide geographic areas if they cannot be disposed of onsite. Therefore, carcasses may need to be transported to an appropriate location. Transportation of carcasses must avoid spillage of animal waste products and prevent the spread of disease to other animals en route. Planning should identify suitable methods for transportation, including storage, packaging, and handling of carcasses, as well as ways to monitor biosecurity.

In the past, large-scale disposal of carcasses has also been contracted to specialty firms that deal with hazardous materials disposal, such as from superfund sites.