Broadly defined as the scientific activity of evaluating the toxic properties of a chemical and the conditions of human exposure to it, with the objective of determining the probability that exposed humans will be adversely affected. Its four main components are: -
Hazard Identification—Does the agent cause the effect?
- Dose-Response Assessment—What is the relationship between the dose and its incidence in human beings?
- Exposure Assessment—What exposures are experienced or anticipated, and under what conditions?
- Risk Characterization—The total analysis producing an estimate of the incidence of the adverse effect in a given population.
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